Zoladex/Zoladex LA Prostate cancer for hormonal manipulation. Zoladex Advanced breast cancer in pre- & peri-menopausal women suitable for hormonal manipulation; alternative to chemotherapy in the standard care for pre-/peri-menopausal women w/ oestrogen receptor (ER)-positive early breast cancer. Endometriosis, endometrial thinning, uterine fibroids, assisted reproduction.
ZoladexAdult 1 depot SC inj into the anterior abdominal wall every 28 days. Assisted reproduction Administered as defined by serum oestradiol levels. Endometriosis Max: 6 mth. Endometrial thinning 2 depots administered 4 wk apart, w/ surgery timed between 0 & 2 wk after 2nd depot. Uterine fibroidsAnaemic women 1 depot w/ supplementary Fe for up to 3 mth pre-op. Elderly, renal & hepatic impairmentNo dose adjustment necessary. Zoladex LAAdult male, elderly 1 depot SC inj into the anterior abdominal wall every 12 wk. Renal or hepatic impairment No dose adjustment necessary.
Zoladex/Zoladex LA May prolong QT interval. Not indicated for use in childn. Zoladex Reduced bone mineral density. Male Patients at risk of developing ureteric obstruction or spinal cord compression. Reduced glucose tolerance, increased risk of developing MI, sudden cardiac death & stroke. Female Metabolic bone disease, uterine cervical resistance, risk of developing ovarian hyperstimulation syndrome (OHSS). Polycystic ovarian syndrome. Zoladex LA Men at risk of ureteric obstruction or spinal cord compression. Reduced glucose tolerance; increased
risk of developing MI, sudden cardiac death & stroke. Not indicated for use in females.
Potential additive effect on QT interval w/ medicinal products that prolong the QT interval or medicinal products able to induce Torsade de Pointes eg, class IA (eg, quinidine, disopyramide) or class III (eg, amiodarone, sotalol, dofetilide, ibutilide) antiarrhythmic medicinal products, methadone, moxifloxacin, antipsychotics.
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